CHEMO-IMMUNOLOGICAL STUDIES ON LOCALIZED INFECTIONS

Chemo-immunological Studies on Localized Infections

Virulent pneumococci injected into the cranial or spinal cavities of monkeys produce constantly a meningitis closely resembling pneumococcus meningitis in man, except that the experimental disease pursues a more rapid course to the invariable death of the untreated animal. An homologous immune pneumococcus serum injected into the spinal canal exerts a restraining influence upon the disease to t...

Chemo-immunological Studies on Conjugated Carbohydrate-proteins

1. Type-specific antipneumococcus immunity has been induced in rabbits by immunization with antigen prepared by combining a specific derivative of the capsular polysaccharide of Type III Pneumococcus with globulin from horse serum. 2. Rabbits immunized with this antigen acquire active immunity against infection with virulent Type III pneumococci. 3. The sera of the immune rabbits contain type-s...

CHEMO-IMMUNOLOGICAL STUDIES ON LOCALIZED INFECTIONS? FIRST PAPER: ACTION ON THE PNEUMOCOCCUS AND ITS EXPERI- _MENTAL INFECTIONS OF CO~IBINED SODIUSf OLEATE AND ANTIPNEUMOCOCCIJS SERUI~

INTRODUCTION. The phenomenon of recovery from any local bacterial infection has not been fully explained, and it is not wholly accounted for by the several activities of blood serum and phagocytes, which have often been viewed as gradually overcoming and removing the offending bacterial agents. Indeed, this restricted view has never been fairly established either by direct observation upon affe...

Chemo-immunological Studies on Conjugated Carbohydrate-proteins Ii. Immunological Specificity of Synthetic Sugar-protein Antigens

The function of carbohydrates as determinative substances in bacterial specificity is well illustrated in the immunological differentiation of thespecific types of pneumococci and of Friedlander bacilli. Previous studies have demonstrated that the presence of type-specific polysaccharides in these encapsulated organisms determines the antigenic properties of the cell and the serological relatio...

Chemo-immunological Studies on Conjugated Carb Ohyd Rate -proteins Xii. the Immunological Properties Oy an Art~icial Antio~.n